Rönnstrand Lab

Recent Publications

Marhäll A, Heidel F, Fischer T and Rönnstrand L (2018) Internal tandem duplications in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation. Ann Hematol Jan 25 [Epub ahead of print]

Marhäll A, Kazi JU and Rönnstrand L (2017) The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation. Sci Rep 7, 13734

Phung B, Kazi JU, Lundby A, , Bergsteinsdottir K, Sun J, Goding CR ,Jönsson G, Olsen JV, Steingrímsson E and Rönnstrand L. (2017) KITD816V induces SRC-mediated tyrosine phosphorylation of MITF and altered transcription program in melanoma. Mol Cancer Res 15, 1265-1274

Kazi JU, Chougule RA, Li T, Su X, Moharram SA, Rupar K, Marhäll A, Gazi M, Sun J, Zhao H and Rönnstrand L (2017) Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD. Cell Mol Life Sci. 74, 2679-2688

Kazi, JU, Rupar K, Marhäll A, Moharram, SA, Khanum F, Shah K, Mohiuddin G, Nagaraj SRM, Sun J, Chougule RA, Rönnstrand L (2017). ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling. Oncotarget. 8, 12194-12202

Moharram SA, Chougule RA,Su X,  Li, T, Sun J, Zhao H, Rönnstrand L and Kazi JU (2016) Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling. Oncotarget; 7, 57770-82

Lindblad O, Cordero E, Puissant A, Macaulay L, Kabir NN, Sun J, Haraldsson K, Borg Å, Levander F, Stegmaier K, Pietras K, Rönnstrand L and Kazi JU. (2016) Aberrant Activation of the PI3K/mTOR Pathway Promotes Resistance to FLT3 Inhibition in AML. Oncogene; 35, 5119-31

Chougule, RA, Cordero, E, Moharram SA, Pietras K, Rönnstrand L and Kazi JU (2016) Expression of GADS enhances FLT3-induced mitogenic signaling. 7, 14112-24

Alam MW, Persson CU, Reinbothe S, Kazi JU, Rönnstrand L, Wigerup C, Ditzel HJ, Lykkesfeldt AE, Påhlman S and Jögi A (2016) HIF2alpha contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells. Oncotarget. 7, 11238-50

Chougule R, Kazi JU and Rönnstrand L (2016) FYN expression potentiates FLT3-ITD-induced STAT5 signaling in acute myeloid leukemia. Oncotarget. 7, 9964-74

Lindblad O, Chougule R, Moharram SA, Kabir NN, Sun J, Kazi JU and Rönnstrand L (2015) The role of HOXB2 and HOXB3 in acute myeloid leukemia. Biochem Biophys Res Commun. 467, 742-7

Kazi JU, Kabir NN and Rönnstrand L (2015) Brain-Expressed X-linked (BEX) proteins in human cancer. BBA Reviews on Cancer. 1856, 226-33. REVIEW

Zhang J, Vakhrusheva O, Bandi SR, Demirel Ö, Kazi JU, Gomes Fernandes R, Jakobi K, Eichler A, Rönnstrand L, Rieger M, Carpino N, Serve H and Brandts CH.(2015) STS1 and STS2 are key regulators of hematopoietic stem and progenitor cells. Stem Cell Reports 5, 633-646

Lindblad O, Li T, Su X, Sun J Kabir NN, Levander F, Zhao H, Lu G, Rönnstrand L and Kazi JU (2015)  BEX1 acts as a tumor suppressor in acute myeloid leukemia. Oncotarget 6, 21395-405

Lindblad O, Kazi JU, Rönnstrand L, Sun J.(2015) PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner. Cell Mol Life Sci 72, 4399-407

Kazi JU, Kabir NN, Rönnstrand L.(2015) Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling. Cell Mol Life Sci 72, 2535-44. REVIEW

Agarwal S, Kazi JU, Mohlin S, Påhlman S and Rönnstrand L (2015) The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V. Oncogene 34, 4581-90